Article
Mitochondrial genome alterations in rectal and sigmoid carcinomas.
Cancer letters - 18 Jul 2009
Pinheiro Manuela, Veiga Isabel, Pinto Carla, Afonso Luís, Sousa Olga, Fragoso Maria, Santos Lúcio, Lopes Paula, Pais Irene, Lopes Carlos, Teixeira Manuel R
Abstract excerpt
The scarce studies on the molecular pathways involved in the pathogenesis of rectal cancer indicate that these may vary, at least in part, from those relevant for colon cancer. Mitochondrial DNA alterations have been described in several human cancers. We aimed to study D310, ND1 and ND5 microsatellite sequence alterations and nuclear microsatellite instability in a series of 38 rectal carcinomas as compared to a...
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