Article
Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm.
Genetics - 1 May 2006
An Xiuxiang, Zhang Zhen, Yang Kui, Huang Mingxia
Abstract excerpt
Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in de novo deoxyribonucleotide biosynthesis and is essential in DNA replication and repair. Cells have evolved complex mechanisms to modulate RNR activity during normal cell cycle progression and in response to genotoxic stress. A recently characterized mode of RNR regulation is DNA damage-induced RNR subunit redistribution. The RNR holoenzyme...
Topics
- Biological Transport, Active
- Cell Nucleus
- Cytoplasm
- DNA Damage
- Dimerization
- Gene Expression
- Mutation
- Nuclear Export Signals
- Protein Transport
- Ribonucleotide Reductases
- Saccharomyces cerevisiae