Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics.

Genes & development - 15 Dec 2015

Wu Jingyan, Bao Alicia, Chatterjee Kunal, Wan Yao, Hopper Anita K

Abstract excerpt

Transfer ribonucleic acids (tRNAs) are essential for protein synthesis. However, key gene products involved in tRNA biogenesis and subcellular movement remain to be discovered. We conducted the first comprehensive unbiased analysis of the role of nearly an entire proteome in tRNA biology and describe 162 novel and 12 previously known Saccharomyces cerevisiae gene products that function in tRNA processing,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cell Nucleus
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Fungal

Share to RNA, Transfer

Share to RNA Transport

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26680305
DOI: 10.1101/gad.269803.115
PMCID: PMC4699390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics.PMID 26680305Read ↗

Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae.Semantic proximity Read ↗

A Los1p-independent pathway for nuclear export of intronless tRNAs in Saccharomycescerevisiae.Semantic proximity Read ↗

Inorganic phosphate deprivation causes tRNA nuclear accumulation via retrograde transport in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease.Semantic proximity Read ↗

tiRNAs & tRFs Biogenesis and Regulation of Diseases: A ReviewSemantic proximity Read ↗

Coordination of tRNA nuclear export with processing of tRNA.Semantic proximity Read ↗

Coordination of tRNA transcription with export at nuclear pore complexes in budding yeast.Semantic proximity Read ↗

An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching.Semantic proximity Read ↗

The mitochondrial protein targeting suppressor (mts1) mutation maps to the mRNA-binding domain of Npl3p and affects translation on cytoplasmic polysomes.Semantic proximity Read ↗

The nuclear tRNA aminoacylation-dependent pathway may be the principal route used to export tRNA from the nucleus in Saccharomyces cerevisiae.Semantic proximity Read ↗

mRNA nuclear export and human disease.Semantic proximity Read ↗

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.