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Article

DNA damage and cell cycle regulation of ribonucleotide reductase.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 May 1993

Elledge S J, Zhou Z, Allen J B, Navas T A

Abstract excerpt

Ribonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. In addition to the well documented allosteric regulation, the synthesis of the enzyme is also tightly regulated at the level of transcription. mRNAs for both subunits are cell cycle regulated and inducible by DNA damage in all organisms examined, including E. coli, S. cerevisiae and...

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PMID: 8343143
DOI: 10.1002/bies.950150507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage and cell cycle regulation of ribonucleotide reductase.PMID 8343143Read ↗

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.Semantic proximity Read ↗

DUN1 encodes a protein kinase that controls the DNA damage response in yeast.Semantic proximity Read ↗

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.Semantic proximity Read ↗

Tolerance to replication stress requires Dun1p kinase and activation of the electron transport chain.Semantic proximity Read ↗

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.Semantic proximity Read ↗

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage.Semantic proximity Read ↗

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.Semantic proximity Read ↗

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.Semantic proximity Read ↗

Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.Semantic proximity Read ↗

Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.Semantic proximity Read ↗

Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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