Article
Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014
Zhang Yan, Li Haoran, Zhang Caiguo, An Xiuxiang, Liu Lili, Stubbe JoAnne, Huang Mingxia
Abstract excerpt
Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)2-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inactivation, and reactivation are poorly understood. Here, we demonstrate that the conserved Fe-S protein-diflavin...
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