Article
Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity.
Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013
Zhuang Jie, Wang Ping-yuan, Huang Xinglu, Chen Xiaoyuan, Kang Ju-Gyeong, Hwang Paul M
Abstract excerpt
p53, a critical tumor suppressor, regulates mitochondrial respiration, but how a nuclear protein can orchestrate the function of an organelle encoded by two separate genomes, both of which require p53 for their integrity, remains unclear. Here we report that the mammalian homolog of the yeast mitochondrial disulfide relay protein Mia40 (CHCHD4) is necessary for the respiratory-dependent translocation of p53 into...
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