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Article

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Oct 1997

Huang M, Elledge S J

Abstract excerpt

Ribonucleotide reductase (RNR), which catalyzes the rate-limiting step for deoxyribonucleotide production required for DNA synthesis, is an alpha2beta2 tetramer consisting of two large and two small subunits. RNR2 encodes a small subunit and is essential for mitotic viability in Saccharomyces cerevisiae. We have cloned a second essential gene encoding a homologous small subunit, RNR4. RNR4 and RNR2 appear to have...

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Identifiers

PMID: 9315670
DOI: 10.1128/MCB.17.10.6105
PMCID: PMC232460

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