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Article

Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Zhang Zhen, An Xiuxiang, Yang Kui, Perlstein Deborah L, Hicks Leslie, Kelleher Neil, Stubbe JoAnne, Huang Mingxia

Abstract excerpt

Ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to the corresponding deoxyribonucleotides and is an essential enzyme for DNA replication and repair. Cells have evolved intricate mechanisms to regulate RNR activity to ensure high fidelity of DNA replication during normal cell-cycle progression and of DNA repair upon genotoxic stress. The RNR holoenzyme is composed of a large subunit R1...

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Identifiers

PMID: 16432237
DOI: 10.1073/pnas.0510516103
PMCID: PMC1360584

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Source receipt: pubmed, retrieved 7 Sept 2026.

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