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Article

Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.

Molecular cell - 10 Oct 2008

Lee Yang David, Wang Jun, Stubbe Joanne, Elledge Stephen J

Abstract excerpt

The control of dNTP concentrations is critical to the fidelity of DNA synthesis and repair. One level of regulation is through subcellular localization of ribonucleotide reductase. In Saccharomyces cerevisiae, the small subunit Rnr2-Rnr4 is nuclear, whereas the large subunit Rnr1 is cytoplasmic. In response to S phase or DNA damage, Rnr2-Rnr4 enters the cytoplasm to bind Rnr1, forming an active complex. We...

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Identifiers

PMID: 18851834
DOI: 10.1016/j.molcel.2008.08.018
PMCID: PMC3245869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.PMID 18851834Read ↗

Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.Semantic proximity Read ↗

Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.Semantic proximity Read ↗

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phenotypes associated with Saccharomyces cerevisiae Hug1 protein, a putative negative regulator of dNTP Levels, reveal similarities and differences with sequence-related Dif1.Semantic proximity Read ↗

Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasm.Semantic proximity Read ↗

Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.Semantic proximity Read ↗

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.Semantic proximity Read ↗

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.Semantic proximity Read ↗

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage.Semantic proximity Read ↗

Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis.Semantic proximity Read ↗

Tolerance to replication stress requires Dun1p kinase and activation of the electron transport chain.Semantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

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