Article
Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.
Molecular cell - 10 Oct 2008
Lee Yang David, Wang Jun, Stubbe Joanne, Elledge Stephen J
Abstract excerpt
The control of dNTP concentrations is critical to the fidelity of DNA synthesis and repair. One level of regulation is through subcellular localization of ribonucleotide reductase. In Saccharomyces cerevisiae, the small subunit Rnr2-Rnr4 is nuclear, whereas the large subunit Rnr1 is cytoplasmic. In response to S phase or DNA damage, Rnr2-Rnr4 enters the cytoplasm to bind Rnr1, forming an active complex. We...
Topics
- Active Transport, Cell Nucleus
- Amino Acid Sequence
- Cell Cycle
- Conserved Sequence
- DNA Damage
- Genes, Fungal
- Intracellular Signaling Peptides and Proteins
- Models, Biological
- Models, Molecular
- Molecular Sequence Data
- Multiprotein Complexes
- Mutation
- Phosphorylation