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Article

Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas.

Journal of the National Cancer Institute - 15 Dec 1993

Urban T, Ricci S, Grange J D, Lacave R, Boudghene F, Breittmayer F, Languille O, Roland J, Bernaudin J F

Abstract excerpt

BACKGROUND: The c-Ki-ras oncogene (also known as KRAS2) is activated by point mutations involving codon 12 in 72%-100% of primary pancreatic adenocarcinomas, but the gene is not activated in nonneoplastic tissues. Therefore, the detection of c-Ki-ras mutations can facilitate the diagnosis of panc...

Topics

Adenocarcinoma
Aged
Aged, 80 and over
Base Sequence
Female
Genes, ras
Genetic Markers
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7902444
DOI: 10.1093/jnci/85.24.2008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7902444-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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