Article
K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.
Cancer - 1 Jan 1998
Wilentz R E, Chung C H, Sturm P D, Musler A, Sohn T A, Offerhaus G J, Yeo C J, Hruban R H, Slebos R J
Abstract excerpt
BACKGROUND: Many patients with carcinoma of the pancreas die because their disease is not detected until late in its course. Methods that detect these cancers earlier will improve patient outcome. Over 80% of pancreatic carcinomas contain mutations in codon 12 of the K-ras gene. Screening duodena...
Topics
- Adenocarcinoma
- Aged
- Ampulla of Vater
- Carcinoma
- Chronic Disease
- Codon
- Common Bile Duct Neoplasms
- DNA Probes
- DNA, Neoplasm
- Duodenum
- Female
- Genes, ras
- Humans
- Intestinal Secretions
- Male
- Middle Aged
- Mutation
- Nucleic Acid Hybridization