Article
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Cancer - 15 Mar 1994
Kondo H, Sugano K, Fukayama N, Kyogoku A, Nose H, Shimada K, Ohkura H, Ohtsu A, Yoshida S, Shimosato Y
Abstract excerpt
BACKGROUND: Mutations in the K-ras oncogene at codon 12 are detected at a remarkably high frequency in pancreatic carcinomas and are believed to be a critical event in oncogenesis. The authors attempted to detect K-ras mutations in DNA obtained from pure pancreatic juice collected endoscopically,...
Topics
- Adenocarcinoma
- Adenoma, Islet Cell
- Adult
- Aged
- Base Sequence
- Carcinoma
- Codon
- DNA
- DNA, Neoplasm
- Female
- Follow-Up Studies
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation
- Pancreas
- Pancreatic Juice