Article
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase.
Developmental biology - 15 Apr 2006
Chubb Jonathan R, Bloomfield Gareth, Xu Qikai, Kaller Markus, Ivens Al, Skelton Jason, Turner Bryan M, Nellen Wolfgang, Shaulsky Gad, Kay Robert R, Bickmore Wendy A, Singer Robert H
Abstract excerpt
Histone-modifying enzymes have enormous potential as regulators of the large-scale changes in gene expression occurring during differentiation. It is unclear how different combinations of histone modification coordinate regimes of transcription during development. We show that different methylation states of lysine 4 of histone H3 (H3K4) mark distinct developmental phases of the simple eukaryote, Dictyostelium....
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