Article

Methylation-directed Acetylation of Histone H3 Regulates Developmental Sensitivity to Histone Deacetylase Inhibition

2020-07-24

Abstract excerpt

<h4>Background</h4> Treatment of cells with hydroxamate-based lysine deacetylase inhibitors (KDACis) such as Trichostatin A (TSA) can induce biological effects such as differentiation or apoptosis of cancer cells, and a number of related compounds have been approved for clinical use. TSA treatment induces rapid initial acetylation of histone 3 (H3) proteins which are already modified by tri-methylation on lysine...

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Literature Corpus work: 74afc025-5d17-58d1-bdce-320835bb0009
DOI: 10.1101/2020.07.22.215665

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