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Article

The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.

Cell - 9 Sept 2005

Zhang Ke, Lin Wenchu, Latham John A, Riefler Gary M, Schumacher Jill M, Chan Clarence, Tatchell Kelly, Hawke David H, Kobayashi Ryuji, Dent Sharon Y R

Abstract excerpt

A balance in the activities of the Ipl Aurora kinase and the Glc7 phosphatase is essential for normal chromosome segregation in yeast. We report here that this balance is modulated by the Set1 methyltransferase. Deletion of SET1 suppresses chromosome loss in ipl1-2 cells. Conversely, combination of SET1 and GLC7 mutations is lethal. Strikingly, these effects are independent of previously defined functions for...

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Identifiers

PMID: 16143104
DOI: 10.1016/j.cell.2005.06.021
PMCID: PMC1794220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.PMID 16143104Read ↗

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