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Article

Developmentally regulated DNA methylation in Dictyostelium discoideum.

Eukaryotic cell - 1 Jan 2006

Katoh Mariko, Curk Tomaz, Xu Qikai, Zupan Blaz, Kuspa Adam, Shaulsky Gad

Abstract excerpt

Methylation of cytosine residues in DNA plays a critical role in the silencing of gene expression, organization of chromatin structure, and cellular differentiation of eukaryotes. Previous studies failed to detect 5-methylcytosine in Dictyostelium genomic DNA, but the recent sequencing of the Dictyostelium genome revealed a candidate DNA methyltransferase gene (dnmA). The genome sequence also uncovered an unusual...

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Identifiers

PMID: 16400165
DOI: 10.1128/EC.5.1.18-25.2006
PMCID: PMC1360260

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