Article
Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.
Development (Cambridge, England) - 1 Jan 2004
Zhukovskaya Natasha V, Fukuzawa Masashi, Tsujioka Masatsune, Jermyn Keith A, Kawata Takefumi, Abe Tomoaki, Zvelebil Marketa, Williams Jeffrey G
Abstract excerpt
Dictyostelium, the only known non-metazoan organism to employ SH2 domain:phosphotyrosine signaling, possesses STATs (signal transducers and activators of transcription) and protein kinases with orthodox SH2 domains. Here, however, we describe a novel Dictyostelium STAT containing a remarkably divergent SH2 domain. Dd-STATb displays a 15 amino acid insertion in its SH2 domain and the conserved and essential...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Dictyostelium
- Dimerization
- Gene Deletion
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Genes, Protozoan
- Models, Molecular