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Article

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.

EMBO reports - 1 Apr 2006

Petretti Clotilde, Savoian Matthew, Montembault Emilie, Glover David M, Prigent Claude, Giet Régis

Abstract excerpt

The CDK11 (cyclin-dependent kinase 11) gene has an internal ribosome entry site (IRES), allowing the expression of two protein kinases. The longer 110-kDa isoform is expressed at constant levels during the cell cycle and the shorter 58-kDa isoform is expressed only during G2 and M phases. By means of RNA interference (RNAi), we show that the CDK11 gene is required for mitotic spindle formation. CDK11 RNAi leads...

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Source

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Identifiers

PMID: 16462731
DOI: 10.1038/sj.embor.7400639
PMCID: PMC1456919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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