Article
Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.
Molecular biology of the cell - 1 Mar 2006
Fourest-Lieuvin Anne, Peris Leticia, Gache Vincent, Garcia-Saez Isabel, Juillan-Binard Céline, Lantez Violaine, Job Didier
Abstract excerpt
The activation of the cyclin-dependent kinase Cdk1 at the transition from interphase to mitosis induces important changes in microtubule dynamics. Cdk1 phosphorylates a number of microtubule- or tubulin-binding proteins but, hitherto, tubulin itself has not been detected as a Cdk1 substrate. Here we show that Cdk1 phosphorylates beta-tubulin both in vitro and in vivo. Phosphorylation occurs on Ser172 of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.