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A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis

6 Feb 2020

Abstract excerpt

During mitosis, translation of most mRNAs is strongly repressed; none of the several explanatory hypotheses suggested can fully explain the molecular basis of this phenomenon. Here we report that cyclin-dependent CDK11/p58-a serine/threonine kinase abundantly expressed during M phase-represses overall translation by phosphorylating a subunit (eIF3F) of the translation factor eIF3 complex that is essential for...

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PMID: 32030451
DOI: 10.1007/s00018-019-03436-3

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