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Article

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

Nature cell biology - 1 Aug 2015

Hanafusa Hiroshi, Kedashiro Shin, Tezuka Motohiro, Funatsu Motoki, Usami Satoshi, Toyoshima Fumiko, Matsumoto Kunihiro

Abstract excerpt

Correct formation of the cell division axis requires the initial precise orientation of the mitotic spindle. Proper spindle orientation depends on centrosome maturation, and Polo-like kinase 1 (PLK1) is known to play a crucial role in this process. However, the molecular mechanisms that function downstream of PLK1 are not well understood. Here we show that LRRK1 is a PLK1 substrate that is phosphorylated on...

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Source

Identifiers

PMID: 26192437
DOI: 10.1038/ncb3204

Genes

PLK1
CDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.PMID 26192437Read ↗

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