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Article

Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation.

The Journal of cell biology - 6 Oct 2008

Royou Anne, McCusker Derek, Kellogg Douglas R, Sullivan William

Abstract excerpt

Entry into mitosis is characterized by a dramatic remodeling of nuclear and cytoplasmic compartments. These changes are driven by cyclin-dependent kinase 1 (CDK1) activity, yet how cytoplasmic and nuclear CDK1 activities are coordinated is unclear. We injected cyclin B (CycB) into Drosophila melanogaster embryos during interphase of syncytial cycles and monitored effects on cytoplasmic and nuclear mitotic events....

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Identifiers

PMID: 18824564
DOI: 10.1083/jcb.200801153
PMCID: PMC2557043

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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