Mutation and genomic deletion status of <i>ataxia telangiectasia mutated</i> ( <i>ATM</i> ) and <i>p53</i> confer specific gene expression profiles in mantle cell lymphoma

Abstract excerpt

Although mantle cell lymphoma (MCL) frequently harbors inactivated ataxia telangiectasia mutated (ATM) and p53 alleles, little is known about the molecular phenotypes caused by these genetic changes. We identified point mutations and genomic deletions in these genes in a series of cyclin D1-positive MCL cases and correlated genotype with gene expression profiles and overall survival. Mutated and/or deleted ATM...

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