Article

<i>SAMHD1</i> mutations in mantle cell lymphoma are recurrent and confer <i>in vitro</i> resistance to nucleoside analogues

2020-06-10

Abstract excerpt

The genomic landscape of mantle cell lymphoma (MCL) includes frequent alterations of TP53 , ATM , CCND1 and KMT2D . Thus far, the mutational landscape provides little information for treatment stratification. We characterized a cohort of MCL by targeted next generation sequencing and discovered SAMHD1 as a novel recurrently mutated gene (8.5% of investigated cases, 4/47 samples). Furthermore, we provide evide...

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Literature Corpus work: d1ab2f92-e0a8-5177-880d-d53f808d6c66
DOI: 10.1101/2020.06.09.140376

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