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Article

ATM and TP53 mutations show mutual exclusivity but distinct clinical impact in mantle cell lymphoma patients

10 Jan 2019

Abstract excerpt

Mantle cell lymphoma (MCL) is characterized by the hallmark t(11;14)(q13;q32) translocation, leading to cyclin D1 over-expression. Additionally, disrupting the DNA damage response pathway through ATM or TP53 defects plays an important role in MCL pathogenesis. Using deep next-generation sequencing we analyzed the mutual composition of ATM and TP53 mutations in 72 MCL patients, and assessed their impact on...

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PMID: 30626249
DOI: 10.1080/10428194.2018.1542144

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