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Article

Mantle cell lymphoma is characterized by inactivation of the ATM gene.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Schaffner C, Idler I, Stilgenbauer S, Döhner H, Lichter P

Abstract excerpt

In mantle cell lymphoma (MCL), the translocation t(11;14) is considered the cytogenetic hallmark of the disease. Recently, however, deletion of the chromosomal region 11q22-q23 has been identified as a frequent event in this type of cancer, indicating the existence of a pathogenically relevant tumor suppressor gene in this region. The deleted segment contains the ATM (ataxia telangiectasia mutated) gene. ATM is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

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Share to In Situ Hybridization, Fluorescence

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Source

Open in PubMed Open full text

Identifiers

PMID: 10706620
DOI: 10.1073/pnas.050400997
PMCID: PMC16005

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mantle cell lymphoma is characterized by inactivation of the ATM gene.PMID 10706620Read ↗

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Molecular Characterization of 11q Deletions Points to a Pathogenic Role of the ATM Gene in Mantle Cell LymphomaSemantic proximity Read ↗

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ATM and TP53 mutations show mutual exclusivity but distinct clinical impact in mantle cell lymphoma patientsSemantic proximity Read ↗

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