Article
ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances.
Blood - 1 Jan 2002
Camacho Emma, Hernández Luis, Hernández Silvia, Tort Frederic, Bellosillo Beatriz, Beà Silvia, Bosch Francesc, Montserrat Emili, Cardesa Antonio, Fernández Pedro L, Campo Elias
Abstract excerpt
The ataxia-telangiectasia mutated (ATM) gene codifies for a protein critically involved in the cellular response to DNA damage. ATM alterations have been observed in some sporadic lymphoproliferative disorders. The recurrent 11q22-23 deletions found in mantle cell lymphoma (MCL) suggest that ATM could be inactivated in these lymphomas. In this study, ATM gene alterations and protein expression were examined in 20...
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