Article
Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling.
Blood - 12 Aug 2010
Hartmann Elena M, Campo Elias, Wright George, Lenz Georg, Salaverria Itziar, Jares Pedro, Xiao Wenming, Braziel Rita M, Rimsza Lisa M, Chan Wing-Chung, Weisenburger Dennis D, Delabie Jan, Jaffe Elaine S, Gascoyne Randy D, Dave Sandeep S, Mueller-Hermelink Hans-Konrad, Staudt Louis M, Ott German, Beà Sílvia, Rosenwald Andreas
Abstract excerpt
The genome of mantle cell lymphoma (MCL) is, in addition to the translocation t(11;14), characterized by a high number of secondary chromosomal gains and losses that probably account for the various survival times of MCL patients. We investigated 77 primary MCL tumors with available clinical information using high-resolution RNA expression and genomic profiling and applied our recently developed gene expression...
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