Article
Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2003
Fang Nicole Y, Greiner Timothy C, Weisenburger Dennis D, Chan Wing C, Vose Julie M, Smith Lynette M, Armitage James O, Mayer R Aeryn, Pike Brian L, Collins Francis S, Hacia Joseph G
Abstract excerpt
Mutations have been described in the ataxia telangiectasia mutated (ATM) gene in small numbers of cases of lymphoid neoplasia. However, surveys of the ATM mutation status in lymphoma have been limited due to the large size (62 exons) and complex mutational spectrum of this gene. We have used microarray-based assays with 250,000 oligonucleotides to screen lymphomas from 120 patients for all possible ATM coding and...
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