Article
Fundamental prognostic difference of ATM gene mutation and deletion in newly diagnosed mantle cell lymphoma.
Molecular medicine (Cambridge, Mass.) - 29 Sept 2025
Obr Ales, Malarikova Diana, Kriegova Eva, Urbankova Helena, Zemanova Zuzana, Manakova Jirina, Petrackova Anna, Vatolikova Michaela, Berkova Adela, Forsterova Kristina, Furst Tomas, Hruskova Andrea, Flodr Patrik, Hanackova Veronika, Prochazka Vit, Papajik Tomas, Trneny Marek, Klener Pavel
Abstract excerpt
BACKGROUND: Previous studies have suggested that, after acquisition of t(11;14), mantle cell lymphoma (MCL) pathogenesis may proceed via several different genetic second hits, which may shape different mutational profiles of clinically manifest lymphoma. The most prevalent second hit in MCL includes ATM aberrations, accounting for about half of patients with newly diagnosed MCL. As ATM and TP53 mutations tend to...
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