Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [<i>p16</i>(<i>INK4a</i>), <i>p15</i>(<i>INK4b</i>), <i>p14</i>(<i>ARF</i>)] in mantle cell lymphoma

Abstract excerpt

Mantle cell lymphoma (MCL) is characterized by the chromosomal translocation t(11;14)(q13;q32), resulting in overexpression of CCND1 in the vast majority of cases. In addition, alterations of other cell-cycle-regulating signal pathways (CDKN2B/CDKN2A-CCND1 and ARF-MDM2-TP53) are frequently observed. However, the hierarchy of promoter methylations and genomic alterations as well as the interaction with other...

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