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Article

c-Met Expression Is Regulated by Mitf in the Melanocyte Lineage

3 Feb 2006

Abstract excerpt

Hepatocyte growth factor (HGF)/c-Met signaling is thought to be a key pathway in both melanocyte development and melanoma metastasis. Here, HGF stimulation of melanocytes was seen to up-regulate c-Met expression. In an effort to decipher the mechanism by which HGF up-regulates its receptor, we found that c-Met is a direct transcriptional target of Mitf. This was confirmed with chromatin immunoprecipitation...

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PMID: 16455654
DOI: 10.1074/jbc.m513094200

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