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Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

15 Feb 2018

Abstract excerpt

c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. The binding of HGF to c-Met initiates a series of intracellular signals that mediate embryogenesis and wound healing in normal cells. However, in cancer cells, aberrant HGF/c-Met axis activation, which is...

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Share to Hepatocellular Carcinoma Treatment and Prognosis
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PMID: 29455668
DOI: 10.1186/s12943-018-0796-y

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