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Article

Targeting the c-Met Signaling Pathway in Cancer

15 Jun 2006

Abstract excerpt

On binding to the cell surface receptor tyrosine kinase (TK) known as c-Met, hepatocyte growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide range of cellular targets including, epithelial and endothelial cells, hematopoietic cells, neurons, melanocytes, and hepatocytes. These pleiotropic actions are fundamentally important during development, homeostasis, and tissue regeneration....

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PMID: 16778093
DOI: 10.1158/1078-0432.ccr-06-0818

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