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Article

Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.

Cytokine & growth factor reviews - 1 Feb 2002

Maulik Gautam, Shrikhande Amol, Kijima Takashi, Ma Patrick C, Morrison Paul T, Salgia Ravi

Abstract excerpt

Receptor tyrosine kinases have become important therapeutic targets for anti-neoplastic molecularly targeted therapies. c-Met is a receptor tyrosine kinase shown to be over-expressed and mutated in a variety of malignancies. Stimulation of c-Met via its ligand hepatocyte growth factor also known as scatter factor (HGF/SF), leads to a plethora of biological and biochemical effects in the cell. There has been...

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Source

Identifiers

PMID: 11750879
DOI: 10.1016/s1359-6101(01)00029-6

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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