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Article

MITF: master regulator of melanocyte development and melanoma oncogene.

Trends in molecular medicine - 1 Sept 2006

Levy Carmit, Khaled Mehdi, Fisher David E

Abstract excerpt

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of melanocyte development, function and survival by modulating various differentiation and cell-cycle progression genes. It has been demonstrated that MITF is an amplified oncogene in a fraction of human melanomas and that it also has an oncogenic role in human clear cell sarcoma. However, MITF also modulates the state of melanocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16899407
DOI: 10.1016/j.molmed.2006.07.008

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MITF: master regulator of melanocyte development and melanoma oncogene.PMID 16899407Read ↗

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read ↗

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma.Semantic proximity Read ↗

Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.Semantic proximity Read ↗

Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.Semantic proximity Read ↗

Melanocytes and the microphthalmia transcription factor network.Semantic proximity Read ↗

MITF, the Janus transcription factor of melanoma.Semantic proximity Read ↗

Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal MelanomaSemantic proximity Read ↗

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.Semantic proximity Read ↗

Diagnostic Utility of Microphthalmia Transcription Factor in Malignant Melanoma and Other TumorsSemantic proximity Read ↗

The small MAF transcription factor MAFG co-opts MITF to promote melanoma progressionSemantic proximity Read ↗

A MAFG~MITF complex drives melanoma phenotype switching and progression.Semantic proximity Read ↗

MITF: a stream flowing for pigment cells.Semantic proximity Read ↗

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