Article
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history.
PLoS genetics - 1 Jan 2006
Traherne James A, Horton Roger, Roberts Anne N, Miretti Marcos M, Hurles Matthew E, Stewart C Andrew, Ashurst Jennifer L, Atrazhev Alexey M, Coggill Penny, Palmer Sophie, Almeida Jeff, Sims Sarah, Wilming Laurens G, Rogers Jane, de Jong Pieter J, Carrington Mary, Elliott John F, Sawcer Stephen, Todd John A, Trowsdale John, Beck Stephan
Abstract excerpt
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of sequence variation across the complex. Highly duplicated and polymorphic regions of the human genome such as the MHC are, however, somewhat refractory to some...
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