Complete MHC haplotype sequencing for common disease gene mapping.

doi:10.1101/gr.2188104

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Article

Complete MHC haplotype sequencing for common disease gene mapping.

Genome research - 1 Jun 2004

Stewart C Andrew, Horton Roger, Allcock Richard J N, Ashurst Jennifer L, Atrazhev Alexey M, Coggill Penny, Dunham Ian, Forbes Simon, Halls Karen, Howson Joanna M M, Humphray Sean J, Hunt Sarah, Mungall Andrew J, Osoegawa Kazutoyo, Palmer Sophie, Roberts Anne N, Rogers Jane, Sims Sarah, Wang Yu, Wilming Laurens G, Elliott John F, de Jong Pieter J, Sawcer Stephen, Todd John A, Trowsdale John, Beck Stephan

Abstract excerpt

The future systematic mapping of variants that confer susceptibility to common diseases requires the construction of a fully informative polymorphism map. Ideally, every base pair of the genome would be sequenced in many individuals. Here, we report 4.75 Mb of contiguous sequence for each of two common haplotypes of the major histocompatibility complex (MHC), to which susceptibility to >100 diseases has been...

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PMID: 15140828
DOI: 10.1101/gr.2188104
PMCID: PMC419796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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