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Article

Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC.

Journal of molecular biology - 11 Sept 1998

Horton R, Niblett D, Milne S, Palmer S, Tubby B, Trowsdale J, Beck S

Abstract excerpt

Comparison of genomic sequences flanking the HLA-DQB1 locus in the human MHC class II region reveals local sequence variation of up to 10%, which is the highest level of sequence variation found in the human genome so far. The variation is haplotype-specific and extends far beyond the transcriptional unit of the DQB1 gene, suggesting hitch-hiking along with functionally selected alleles as the most likely...

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Source

Identifiers

PMID: 9733642
DOI: 10.1006/jmbi.1998.2018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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