Article
Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC.
Journal of molecular biology - 11 Sept 1998
Horton R, Niblett D, Milne S, Palmer S, Tubby B, Trowsdale J, Beck S
Abstract excerpt
Comparison of genomic sequences flanking the HLA-DQB1 locus in the human MHC class II region reveals local sequence variation of up to 10%, which is the highest level of sequence variation found in the human genome so far. The variation is haplotype-specific and extends far beyond the transcripti...
Topics
- Ataxin-1
- Ataxins
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Gene Expression Regulation
- Genes, MHC Class II
- Genetic Variation
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Humans
- Molecular Sequence Data
- Mutagenesis, Insertional
- Nerve Tissue Proteins
- Nuclear Proteins
- Retroviridae
- Sequence Analysis, DNA
- Sequence Deletion