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Article

Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides.

BMC genomics - 26 Jan 2006

Crowe Mark L, Wang Xue-Qing, Rothnagel Joseph A

Abstract excerpt

BACKGROUND: Approximately 40% of mammalian mRNA sequences contain AUG trinucleotides upstream of the main coding sequence, with a quarter of these AUGs demarcating open reading frames of 20 or more codons. In order to investigate whether these open reading frames may encode functional peptides, we have carried out a comparative genomic analysis of human and mouse mRNA 'untranslated regions' using sequences from...

Topics

3' Untranslated Regions
5' Untranslated Regions
Animals
Codon
Consensus Sequence
Evolution, Molecular
Humans
Mice
Mutation
Open Reading Frames
Peptide Chain Initiation, Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptides

RNA, Messenger

Selection, Genetic

Sequence Homology, Nucleic Acid

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 16438715
DOI: 10.1186/1471-2164-7-16
PMCID: PMC1402274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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