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Article

Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides.

BMC genomics - 26 Jan 2006

Crowe Mark L, Wang Xue-Qing, Rothnagel Joseph A

Abstract excerpt

BACKGROUND: Approximately 40% of mammalian mRNA sequences contain AUG trinucleotides upstream of the main coding sequence, with a quarter of these AUGs demarcating open reading frames of 20 or more codons. In order to investigate whether these open reading frames may encode functional peptides, we have carried out a comparative genomic analysis of human and mouse mRNA 'untranslated regions' using sequences from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16438715
DOI: 10.1186/1471-2164-7-16
PMCID: PMC1402274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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