Article

Autonomous functionality of an upstream open reading frame in polycistronic mammalian mRNAs

2018-05-26

Abstract excerpt

<h4>SUMMARY</h4> Upstream open reading frames (uORFs) are established as cis -acting elements for eukaryotic translation of annotated ORFs (anORFs) located on the same mRNAs. Here, we identified a mammalian uORF with functions that are independent from anORF translation regulation. Bioinformatics screening using ribosome profiling data of human and mouse brains yielded 308 neurologically vital genes from which a...

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Literature Corpus work: 32a6b736-c8b7-5fbd-8c93-289f4a6c5013
DOI: 10.1101/325571

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