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Article

Analysis of human upstream open reading frames and impact on gene expression.

Human genetics - 1 Jun 2015

Ye Yuhua, Liang Yidan, Yu Qiuxia, Hu Lingling, Li Haoli, Zhang Zhenhai, Xu Xiangmin

Abstract excerpt

The upstream open reading frame (uORF) is a post-transcriptional regulatory element in the 5' untranslated region (5'UTR), which modulates the translation levels of main open reading frame (mORF). Earlier studies showed that disturbed uORF-mediated translation control can result in drastic changes in translation levels of mORF, leading to genetic disorders. To date, there has been no systematic investigation into...

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PMID: 25800702
DOI: 10.1007/s00439-015-1544-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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