[Assessment of the presence of mutations of the epidermal growth factor receptors in tumors of various histologies].

Article

[Assessment of the presence of mutations of the epidermal growth factor receptors in tumors of various histologies].

I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] - 1 Jan 2000

Leone A, Pisa R, Gasbarra R, Costanzi-Porrini S, Cavazzana A, Bevilacqua G, Graziano P, Remotti D, Valle M, Garofalo A

Abstract excerpt

Recent reports from US and Japan have established that mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (Egfr) occur in a subset of patients with lung cancer that respond to therapy with gefitinib, a TK inhibitor. To gain further insights into the role of Egfr...

Topics

ErbB Receptors
Humans
Mutation
Neoplasms

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