Article
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
Proceedings of the National Academy of Sciences of the United States of America - 7 Sept 2004
Pao William, Miller Vincent, Zakowski Maureen, Doherty Jennifer, Politi Katerina, Sarkaria Inderpal, Singh Bhuvanesh, Heelan Robert, Rusch Valerie, Fulton Lucinda, Mardis Elaine, Kupfer Doris, Wilson Richard, Kris Mark, Varmus Harold
Abstract excerpt
Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), kinase inhibitor. In-frame deletions occur in exon 19, whereas point mutations occur frequently in codon 858 (exon 21). We found from sequencing the EGFR TK domain that 7 of 10 gefitinib-sensitive tumors had similar types of...
Topics
- Adenocarcinoma
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- ErbB Receptors
- Erlotinib Hydrochloride
- Female
- Gefitinib
- Humans