Article
[Mutations in exon 19 of EGFR gene in non-small cell lung cancer from Chinese patients].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Jun 2008
Wang He-yong, Luo Hen, Zhao Yin-min, Tang Liang, Zhou Cai-cun
Abstract excerpt
OBJECTIVE: To investigate the mutations in exon 19 of epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer from Chinese patients. METHODS: Genomic DNA was extracted from 72 lung cancer tissues. Then the exon 19 of EGFR gene was amplified by nested PCR and sequenced. RESULTS: In 13 tumor tissues, multi-nucleotide in-frame deletion mutations at the exon 19 of EGFR gene, had been detected....
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