Article
Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer.
Chinese medical journal - 1 Aug 2011
Huang Yi-Sheng, Yang Jin-Ji, Zhang Xu-Chao, Yang Xue-Ning, Huang Yu-Juan, Xu Chong-Rui, Zhou Qing, Wang Zhen, Su Jian, Wu Yi-Long
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations in lung carcinomas can make the disease more responsive to the treatment with tyrosine kinase inhibitors. We aimed to evaluate the prevalence of EGFR mutations in a large series of lung carcinomas. METHODS: We examined 1195 consecutive lung cancer patients for EGFR mutations in exons 18, 19, and 21 using direct sequencing of polymerase chain reaction...
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