Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.

Cancer research - 15 Dec 2004

Kosaka Takayuki, Yatabe Yasushi, Endoh Hideki, Kuwano Hiroyuki, Takahashi Takashi, Mitsudomi Tetsuya

Abstract excerpt

Recently it has been reported that mutations in the tyrosine kinase domain of the epidermal growth factor receptor(EGFR) gene occur in a subset of patients with lung cancer showing a dramatic response to EGFR tyrosine kinase inhibitors. To gain further insights in the role of EGFR in lung carcinogenesis, we sequenced exons 18-21 of the tyrosine kinase domain using total RNA extracted from unselected 277 patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Gene Deletion

Share to Genes, erbB-1

Share to Genes, p53

Share to Genes, ras

Share to Lung Neoplasms

Source

Identifiers

PMID: 15604253
DOI: 10.1158/0008-5472.CAN-04-2818

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications.PMID 15604253Read ↗

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.Semantic proximity Read ↗

Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smokingSemantic proximity Read ↗

Epidermal growth factor receptor mutations in lung cancers.Semantic proximity Read ↗

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.Semantic proximity Read ↗

Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer.Semantic proximity Read ↗

Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors.Semantic proximity Read ↗

Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer.Semantic proximity Read ↗

Pharmacogenetics of EGFR in Lung Cancer: Perspectives and Clinical ApplicationsSemantic proximity Read ↗

Epidermal growth factor receptor mutation in non-small-cell lung carcinomas: a retrospective analysis of 1036 lung cancer specimens from a network of tertiary cancer care centers in India.Semantic proximity Read ↗

Epidermal growth factor receptor abnormalities in lung cancer. Pathogenetic and clinical implications.Semantic proximity Read ↗

Mutations of the epidermal growth factor receptor gene in NSCLC patientsSemantic proximity Read ↗

Mutational Damages in Malignant Lung Tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.