Article
Epidermal growth factor receptor mutations in lung cancers.
Pathology international - 1 May 2007
Yatabe Yasushi, Mitsudomi Tetsuya
Abstract excerpt
In 2004, two groups reported somatic mutations in the gene for the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC), which were highly correlated with the clinical response to the anticancer drug, gefitinib. Since then, a tremendous amount of knowledge has accumulated, and sheds light on significant oncological properties as well as the clinical relevance of this...
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