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Article

Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi.

Antimicrobial agents and chemotherapy - 1 Feb 2006

Criswell Daniel, Tobiason Virginia L, Lodmell J Stephen, Samuels D Scott

Abstract excerpt

We have isolated and characterized in vitro mutants of the Lyme disease agent Borrelia burgdorferi that are resistant to spectinomycin, kanamycin, gentamicin, or streptomycin, antibiotics that target the small subunit of the ribosome. 16S rRNA mutations A1185G and C1186U, homologous to Escherichia coli nucleotides A1191 and C1192, conferred >2,200-fold and 1,300-fold resistance to spectinomycin, respectively. A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16436695
DOI: 10.1128/AAC.50.2.445-452.2006
PMCID: PMC1366916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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