Article
A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae.
The Journal of infectious diseases - 1 Jun 1998
Prammananan T, Sander P, Brown B A, Frischkorn K, Onyi G O, Zhang Y, Böttger E C, Wallace R J
Abstract excerpt
Twenty-six clinical isolates of Mycobacterium abscessus resistant to amikacin were identified. Most isolates were from patients with posttympanostomy tube placement otitis media or patients with cystic fibrosis who had received aminoglycoside therapy. Isolates were highly resistant (MICs > 1024 m...
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